Understand your values of ASAT (GOT) (UI/l)

What is ASAT (GOT) and its measure units?

ASAT, also known as Aspartate Aminotransferase (AST) or Glutamate Oxaloacetate Transaminase (GOT), is an important enzyme found in various tissues in the body, including the liver, heart, and muscles. It plays a crucial role in amino acid metabolism. When cells in these tissues are damaged, ASAT is released into the bloodstream, making it a useful marker in blood tests to assess organ health, particularly liver function.

The unit of measurement for ASAT (GOT) levels in the blood is typically expressed in units per liter (UI/l). Monitoring ASAT levels can help in diagnosing and managing health conditions, particularly those affecting the liver and heart.

Which is the function of ASAT (GOT) in our bodies?

ASAT (GOT) is an enzyme that acts as a catalyst in the conversion process between amino acids and keto acids. It facilitates the transfer of an amino group from aspartate, an amino acid, to alpha-ketoglutarate, a keto acid, forming glutamate and oxaloacetate. This process is vital in the urea and amino acid cycles, which are essential for removing excess nitrogen from our bodies and for the metabolism of nutrients.

Beyond its metabolic functions, ASAT is found in high concentrations in tissues that require high energy, such as the heart and liver. Therefore, the levels of ASAT in the bloodstream are often used as clinical indicators of tissue health, particularly in these organs.

What happens if we have values of ASAT (GOT) out of normal?

When ASAT (GOT) levels are elevated, it can be an indication of tissue damage or stress, especially in the liver or heart. Common causes of elevated ASAT include acute liver disease, such as hepatitis, alcohol liver disease, heart diseases like myocardial infarction (heart attack), or muscle injuries. Sometimes, medications, toxins, or even excessive exercise can lead to elevated ASAT levels.

Conversely, low ASAT levels are not typically seen as concerning and are much less common in clinical settings. However, they may indicate a vitamin B6 deficiency, as this vitamin is a cofactor for the normal activity of the enzyme.

If you discover that your ASAT levels are abnormal, it is important to consult with a healthcare professional to determine the underlying cause and appropriate treatment.

Which are the optimum values of ASAT (GOT) and what should we do to improve our values of this substance?

The normal range for ASAT (GOT) levels varies slightly depending on the laboratory and the method used, but it generally falls between 10 to 40 UI/l for adults. To ensure levels remain within this range, several lifestyle modifications can be beneficial:

• Maintain a healthy diet: Incorporate plenty of fruits, vegetables, whole grains, and lean proteins into your diet. Avoid processed foods and excessive alcohol which can damage the liver and elevate ASAT levels.
• Regular exercise: Engage in regular physical activity to improve cardiovascular and liver health, but avoid over-exercising as it may cause muscle damage and temporarily elevate ASAT.
• Limit alcohol intake: Excessive alcohol can lead to liver damage, elevating ASAT levels.
• Medication management: Be aware of medications and substances that may raise ASAT levels, and discuss alternatives with your healthcare provider if necessary.
• Regular monitoring: If you are at risk of liver or heart diseases, regular monitoring of ASAT levels can help you address issues early.

Consistently healthy lifestyle choices are instrumental in maintaining optimal ASAT levels.

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